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OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study.Patients are stratified according to disease type (breast vs colorectal female vs colorectal male), age (49 and under vs 50-69 vs 70 and over), ECOG performance status (0-1 vs 2), baseline quality of life (UNISCALE rating less than 50% vs 50-75% vs more than 75%), and concurrent chemotherapy (yes vs no). Choosing to participate in a study is an important personal decision.The incidence rate of colorectal cancer among cholecystectomy patients (n = 55,960) was 119 (95% CI: 106–133) per 100,000 person-years, compared to 86 (95% CI: 83–90) per 100,000 person-years among patients without a cholecystectomy (n = 574,668).

Further, the associations between birth weight and colon and rectal cancer differed significantly from each other (p = 0.006).The anus contains the internal anal sphincter, which is composed of smooth muscle and is not under voluntary control, and the external sphincter, which is composed of skeletal voluntary muscle.The intrinsic nervous system, also known as the enteric nervous system, is composed of the submucosal (ie, Meissner) and myenteric (ie, Auerbach) plexuses (see the image below), which largely regulate segment-to-segment movement of the GI tract.However, the clinical evidence and the underlying mechanism for this association are still inconclusive.We conducted a population-based study to further clarify this association.

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